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Weird gloop is a substance in a bucket that can be created during The Eyes of Glouphrie by using a hammer on a rune essence or pure essence, grinding the rune shards with a pestle and mortar, and using the rune dust on a bucket of sap. The resulting bucket of weird gloop has no use, but can be emptied to retain the bucket.

It is sometimes made during The Eyes of Glouphrie when trying to make magic glue for Brimstail. Instead of using rune essence, players must use ground mud runes on the bucket of sap.